What is Myolysis? - A Definition and Explanation

What is Myolysis? - A Definition and Explanation
Myolysis, more commonly known as myomectomy, is the medical term used to describe the removal of uterine fibroids. In the US, myomectomy procedures are frequently done in women who have experienced fertility issues and those who have had severe or frequent miscarriages or stillbirths. The choice to undergo myomectomy is often made when other treatments, such as hormone therapy or hysterectomy, fail to reduce symptoms or improve fertility rates.

Myolysis, also known as myotomy, refers to the surgical procedure of making an incision into a fibroid in order to reduce its size or eliminate it completely. Fibroids are non-cancerous tumors that can grow inside the wall of the uterus and cause symptoms ranging from severe pain to heavy bleeding during menstruation. Myolysis is considered to be one of the most effective procedures used to treat this condition and can be performed in several different ways depending on the severity of the symptoms and the medical history of the patient.

What is Myolysis? - A Definition and Explanation

Research shows that many women experience abnormal uterine bleeding in their lifetime, with the biggest percentage of these women experiencing it during their pre-menopausal years. Doctors have come up with different medical terms to describe this abnormal uterine bleeding, but there are many women who are not familiar with the terminology and may feel uncomfortable asking their doctor about it. For this reason, we’ve created this article on what is myolysis to help you learn more about abnormal uterine bleeding, its symptoms, and how doctors diagnose and treat it if necessary.

What is myolysis?

Myolysis means breaking down muscle cells with chemicals. It's a treatment for myoma or uterine fibroids. Fibroids are tumors that develop in the uterus, often as a result of an imbalance of estrogen levels. Chemical injections break down the cells making up these benign tumors in the uterus.

What are the symptoms of myolysis?

1. Pain in the lower back, buttocks, or legs with prolonged standing or sitting 

2. Shortness of breath, especially when lying down or breathing deeply 

3. Difficulty swallowing 

4. Sensations of tingling, pain, tightness, pressure, fullness in the throat or chest 

5. Difficulty eating or feeling full quickly 

6. Inability to control the sphincter muscles that hold in bowel movements 

7. Frequent urination and urgency to go despite having little urine volume

How does myolysis occur in humans?

Myolysis is the breakdown of muscle tissue that occurs with prolonged or repetitive muscular contraction. It can also occur in response to injury. The breakdown of these tissues releases myoglobin, creatinine, electrolytes, and other substances into the bloodstream. These products circulate through the body until they reach their final destination such as muscles or kidneys where they are cleared from the body. This process can take up to a few hours, depending on how much myoglobin was released into the bloodstream when it happened.

What is Myolysis? - A Definition and Explanation

Can myolysis be prevented or treated early on?

There are many reasons a woman may experience fibroids, and they can be treated when caught early. The only way to diagnose the cause of fibroids in any woman's body, though, is through MRI imaging. This will take place if a woman has been experiencing any abnormal symptoms or she doesn't get her period for six months.

Does myolysis cause symptoms in men too?

There are many causes of fibroids, and a variety of treatments for them. The most common cause of fibroids in women is genetics. Family history of fibroids can be a leading factor. There are also cases where estrogen levels increase, causing the uterine wall to thicken because it's been stretched out from an earlier pregnancy, which increases a woman's risk of developing fibroids. Some things you might experience from myolysis include abdominal pain, persistent vaginal bleeding after childbirth or an abortion, or changes in your menstrual cycle such as prolonged menstrual periods or spotting between periods. 

  • No, myolysis only happens to females so males have nothing to worry about with this disease.

Is myolysis inherited from family members, friends, or blood relatives like parents, siblings, aunts, uncles, cousins, and grandparents?

1. Low thyroid function can lead to a low metabolic rate, also known as hypothyroidism, which then causes a fibroid tumor.

2. Hypothyroidism slows down the metabolism of hormones, resulting in enlargement of the uterus or other parts of the body that use those hormones to grow or maintain tissues such as muscles, skin, bones, and hair follicles (Becker 2010). 

3. There are three types of hypothyroidism: Autoimmune-Based Idiopathic-Iatrogenic.

4. The autoimmune type occurs when the immune system reacts against healthy tissue inside organs in the body called autoimmune disease(Becker 2010).

Is it possible to develop familial myolysis (FM)?

Since FM is a genetic disease, it's possible to develop the condition. There are a few different ways this could happen. You might have been born with the defective gene or received the defective gene from your mother or father. In these cases, you can't do anything to prevent it from happening to you. On the other hand, if you're a carrier of FM, meaning that you only have one copy of the defective gene in your DNA code and don't have symptoms of FM, you could be at risk for developing symptoms when other risk factors are present such as having increased levels of testosterone production in men.

Is it possible to donate myocytes during transplant surgery?

Some donors will even be able to recover from the surgery and go on with their lives. In other cases, such as in the case of donation after cardiac death, donors may not survive. Doctors are cautious about allowing live donors because some die during the process. This means the donor must wait at least a year after their health improves before they can donate again.

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